Population
13 simian cell lines and 70 athymic, 30-day-old male mice (Nu/Nu genotype) for in vivo tumorigenicity testing
Comparison
In vitro transformation assay, in vivo… vs Positive control and negative control
Design
Preclinical
Follow-up
12 weeks
Authors
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Identified simian lines show no tumorigenicity and support Sabin poliovirus replication; leaves open adoption pending scaled manufacturing and regulatory studies.
CYNOM-K1, FRhK-4, 4MBr-5 and 4647 cell lines are safe, non-tumorigenic substrates suitable for large-scale Poliovirus vaccine production.
Dotti et al. (2017) studied this question.
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