Answers are grounded in this paper and cite their sources.
Antiviral therapy with pocapavir and remdesivir failed to clear iVDPV in a pediatric patient with combined immunodeficiency.
Immunodeficiency-related vaccine-derived poliovirus (iVDPV) was detected in the stool of a 5-year-old male patient with combined immunodeficiency. The patient presented in August 2019 with chronic diarrhea, fever, and generalized weakness. This case was identified concurrently with the 2019-2020 poliovirus outbreak in the Philippines. Antiviral therapy with pocapavir and remdesivir was administered but was unsuccessful in iVDPV clearance. The patient remained a chronic iVDPV excretor until his death in 2023.
No takes yet. Share an insight, caveat, or question.
Co et al. (2025) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: