Auto-Immunization and Auto-Antibodies

Editorial1 April 1960AUTO-IMMUNIZATION AND AUTO-ANTIBODIESPAUL W. CLOUGH, M.D.PAUL W. CLOUGH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-4-930 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe capacity of the animal body to react to the presence of microorganisms or other foreign organic material as a protective measure has been well known for over half a century. Much has been learned regarding the mechanisms by which this is accomplished and the circulating antibodies which participate in providing this immunity. Under natural conditions these reactions are nearly always beneficial if they are efficient, and the term immunity has come to indicate a favorable and highly desirable state. The introduction into the body of blood or tissue products of another individual of the same species will often stimulate...1 DameshekSchwartz WSO: Hemolysins as the cause of clinical and experimental hemolytic anemias with particular reference to the nature of spherocytosis and increased fragility, Am. J. M. Sc. 196: 759, 1938. CrossrefGoogle Scholar2 WitebskyRose ENR: Studies on organ specificity. IV. Production of rabbit thyroid antibodies in rabbit, J. Immunol. 76: 408-416 (June) 1956. MedlineGoogle Scholar3 RoitDoniachCampbellHudson IMDPNRV: Autoantibodies in Hashimoto's disease (lymphadenoid goitre), Lancet 2: 820-821, 1956. CrossrefGoogle Scholar4 WitebskyRoseTerplanPaineEgan ENRKJRRW: Chronic thyroiditis and autoimmunization, J. A. M. A. 164: 1439-1447 (July 27) 1957. CrossrefMedlineGoogle Scholar5 RoseWitebsky NRE: Studies on organ specificity. V. Changes in thyroid glands of rabbits following active immunization with rabbit thyroid extracts, J. Immunol. 76: 417-427 (June) 1956. MedlineGoogle Scholar6 Gear J: Autoantibodies and the hyperreactive state in the pathogenesis of disease, Acta med. scandinav. 152, Supp. 306: 39-55, 1955. MedlineGoogle Scholar7 Vaughan JH: Serum responses in rheumatoid arthritis, Am. J. Med. 26: 596-613 (Apr.) 1959. (Good review.) CrossrefMedlineGoogle Scholar8 Good RA: Rheumatoid arthritis and agammaglobulinemia, Bull. Rheumat. Dis. 10: 203-206 (Jan.) 1960. MedlineGoogle Scholar9 JanewayGitlinCraigGrice CADJMDS: "Collagen disease" in patients with congenital agammaglobulinemia, Tr. A. Am. Physicians 69: 93-97, 1956. MedlineGoogle Scholar10 Gajdusek DC: An "autoimmune" reaction against human tissue antigens in certain acute and chronic diseases. I. Serological investigations, Arch. Int. Med. 101: 9-29 (Jan.) 1958. CrossrefGoogle Scholar11 MackayGajdusek IRDC: An "autoimmune" reaction against human tissue antigens in certain acute and chronic diseases. II. Clinical correlations, Arch. Int. Med. 101: 30-46 (Jan.) 1958. CrossrefGoogle Scholar12 Vorlaender KO: Weitere Untersuchungen zur Frage der klinischen Bedeutung von Antikörpernachweisen beim Rheumatismus und entzündlichen Erkrankungen, Ztschr. f. d. ges. exper. Med. 120: 9-22, 1952. CrossrefMedlineGoogle Scholar13 Smadel J: Experimental nephritis in rats induced by injection of antikidney serum: preparation and immunological studies of nephrotoxin, J. Exper. Med. 64: 921-942, 1936. CrossrefMedlineGoogle Scholar14 Schmidt H: Auto-antikörper, Verhandl. deutsch. Gesellsch. inn. Med., Kong. 60: 232-242, 1954. CrossrefGoogle Scholar15 Vorlaender KO: Neuere Ergebnisse zum Auto-immunisierungsproblem, Verhandl. deutsch. Gesellsch. inn. Med., Kong. 60: 242-249, 1954. CrossrefGoogle Scholar16 Vorlaender KO: Über der Nachweis komplementbindender Auto-antikorper bei Nieren- und Lebererkrankungen, Ztschr. f. d. ges. exper. Med. 118: 352-372, 1952. CrossrefMedlineGoogle Scholar17 BaxterGoodman JHHC: Nephrotoxic serum nephritis in rabbits. I. Distribution and specificity of the antigen responsible for the production of nephrotoxic antibodies, J. Exper. Med. 104: 467-485, 1956. CrossrefMedlineGoogle Scholar18 LiuMcCrory CTWW: Autoantibodies in human glomerulonephritis and nephrotic syndrome, J. Immunol. 81: 492, 1958. MedlineGoogle Scholar19 BrobergerPerlman OP: Autoantibodies in human ulcerative colitis, J. Exper. Med. 110: 657-674 (Nov.) 1959. CrossrefMedlineGoogle Scholar20 Dameshek W: Systemic lupus erythematosus: a complex auto-immune disorder, Ann. Int. Med. 48: 707-730 (Apr.) 1958. LinkGoogle Scholar21 Conley CL: The L. E. cell test, J. Chron. Dis. 5: 275, 1957. CrossrefMedlineGoogle Scholar22 DeicherHolmanKunkel HRHRHG: The precipitin reaction between DNA and a serum factor in systemic lupus erythematosus, J. Exper. Med. 109: 97-114 (Jan.) 1959. CrossrefMedlineGoogle Scholar23 MellorsOrtegaHolman RCLGHR: Role of gamma globulin in the pathogenesis of renal lesions in systemic lupus erythematosus and chronic membranous glomerulonephritis, with an observation on the lupus erythematosus cell reaction, J. Exper. Med. 106: 191-202, 1957. CrossrefMedlineGoogle Scholar24 HolborowWeirJohnson EJDMGD: A serum factor in lupus erythematosus with affinity for tissue nuclei, Brit. M. J. 2: 732, 1957. CrossrefMedlineGoogle Scholar25 HarveySchulmanTumultyConleySchoenrich AMLEPACLEH: Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases, Medicine 33: 291, 1954. CrossrefMedlineGoogle Scholar26 BurnetFenner FMF: The production of antibodies, monograph of the Walter and Eliza Hall Institute, 2nd Ed., 1949, Macmillan and Co. Ltd., Melbourne, Australia. Google Scholar27 BardawilToyGalensBayles WABLNTB: Disseminated lupus erythematosus, scleroderma and dermatomyositis as manifestations of sensitization to DNA-protein. I. An immunohistochemical approach, Am. J. Path. 31: 607, 1958. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMechanical properties and cold-brittleness threshold of vanadiumBIBLIOGRAPHYClinical Studies in ThyroiditisW. C. THOMAS JR., M.D., F.A.C.P., R. M. ANDERSON, M.D., M. J. JURKIEWICZ, M.D., J. D. ARAUJO, M.D., R. M. BLIZZARD, M.D.Rheumatism and Arthritis Review of American and English Literature of Recent Years (Fifteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., FELIX E. DEMARTINI, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., EDWARD C. FRANKLIN, M.D., DONALD F. HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., HOWARD L. HOLLEY, M.D., F.A.C.P., JOHN G. MAYNE, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., CHARLES L. SHORT, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), OTTO STEINBROCKER, M.D.Eigenschaften der Va-MetalleThe Asthma Problem A Critical AnalysisOSCAR SWINEFORD JR., M.D.The Biologically Defenseless PatientAutoimmune Addison's Disease 1 April 1960Volume 52, Issue 4Page: 930-939KeywordsAntibodiesBloodImmunity ePublished: 1 December 2008 Issue Published: 1 April 1960 PDF downloadLoading ...