Population
Three pharmacokinetic datasets used as examples: 18 patients with diastolic blood pressure 100-115 mmHg…
Comparison
Nonlinear mixed effect modelling (NONMEM) vs Standard nonlinear regression
Design
Other
Authors
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May facilitate PK studies with sparse sampling; leaves open routine clinical adoption pending validation.
Nonlinear mixed effect modelling (NONMEM) effectively integrates data across subjects to estimate pharmacokinetic parameters when individual data are insufficient.
Schoemaker et al. (1996) studied this question.
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