The identification of VAPP cases following OPV immunization in Uganda supports the global strategy to transition from OPV to IPV to prevent vaccine-derived paralysis.
VAPP cases occurred after OPV in this cohort; hypothesis-generating for IPV transition benefits but should not yet change practice.
A retrospective study to identify VAPP cases from the entire Uganda was conducted between January 2003 and December 2011. Eleven of the 106 AFP cases were VAPPs. The VAPP rate ranged from 0 to 3.39 cases per 1,000,000 birth cohorts and the peak was in 2009 when there was scaling up of OPV immunization activities following an importation of wild poliovirus in the country. All the subsequent polio suspect cases since then have been vaccine-associated polio cases. Our data support the strategy to withdraw OPV and introduce IPV progressively in order to mitigate against the paralysis arising from Sabin polioviruses.
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Nanteza et al. (2015) studied this question.
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