What is the clinical evidence from this study?

Study design: Observational. Population: Poliomyelitis. Intervention: Oral poliovirus vaccine (OPV). Primary outcome: Incidence of vaccine-associated paralytic poliomyelitis (VAPP).

What does this research mean for the field?

Oral poliovirus vaccine (OPV) is associated with a low but stable risk of vaccine-associated paralytic poliomyelitis (1 case per 2.5 million doses), which has emerged as the predominant form of the disease in the United States and primarily affects first-dose recipients, their contacts, and immunologically abnormal individuals. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1992Clinical Infectious Diseases

Epidemiology of Poliomyelitis in the United States One Decade after the Last Reported Case of Indigenous Wild Virus-Associated Disease

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Why the study?

What is the risk of vaccine-associated paralytic poliomyelitis following oral poliovirus vaccine administration in the United States?

Population

Poliomyelitis cases in the United States reported in national surveillance data from 1960-1989, with a focus…

Design

Cohort

Follow-up

1960-1989

Key result

Oral poliovirus vaccine (OPV) was associated with a low but stable risk of vaccine-associated paralytic poliomyelitis, with 1 case per 2.5 million doses distributed during 1980-1989.

Authors

PSPeter Strebel RSRoland W. Sutter SCStephen L. Cochi

Discussion

Member takes

Overview

Low stable VAPP risk with OPV may support surveillance; leaves open benefits of sequential IPV-OPV schedules.

Study Design

Type

Observational

Structured PICO

What is the risk of vaccine-associated paralytic poliomyelitis following oral poliovirus vaccine administration in the United States?

Population

Poliomyelitis cases in the United States reported in national surveillance data from 1960-1989, with a focus on the period 1980-1989.

Intervention

Oral poliovirus vaccine (OPV)

Outcome

Incidence of wild-virus, vaccine-associated, and imported paralytic poliomyelitissafety

Vaccine-associated paralytic poliomyelitis has become the predominant form of the disease in the US, suggesting a sequential vaccination schedule (IPV followed by OPV) may reduce risk.

Cite This Study

Strebel et al. (1992) conducted an observational in Poliomyelitis. Oral poliovirus vaccine (OPV) was evaluated on Incidence of vaccine-associated paralytic poliomyelitis (VAPP). Oral poliovirus vaccine (OPV) was associated with a low but stable risk of vaccine-associated paralytic poliomyelitis, with 1 case per 2.5 million doses distributed during 1980-1989.

synapsesocial.com/papers/6a158f60a2f71238514e89f3 https://doi.org/10.1093/clinids/14.2.568

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February 1, 1992Clinical Infectious Diseases

Epidemiology of Poliomyelitis in the United States One Decade after the Last Reported Case of Indigenous Wild Virus-Associated Disease

View Full Paper

Ask AI

Bookmark

Why the study?

What is the risk of vaccine-associated paralytic poliomyelitis following oral poliovirus vaccine administration in the United States?

Population

Poliomyelitis cases in the United States reported in national surveillance data from 1960-1989, with a focus…

Design

Cohort

Follow-up

1960-1989

Key result

Oral poliovirus vaccine (OPV) was associated with a low but stable risk of vaccine-associated paralytic poliomyelitis, with 1 case per 2.5 million doses distributed during 1980-1989.

Authors

PSPeter Strebel RSRoland W. Sutter SCStephen L. Cochi

Discussion

Member takes

Overview

Low stable VAPP risk with OPV may support surveillance; leaves open benefits of sequential IPV-OPV schedules.

Study Design

Type

Observational

Structured PICO

What is the risk of vaccine-associated paralytic poliomyelitis following oral poliovirus vaccine administration in the United States?

Population

Poliomyelitis cases in the United States reported in national surveillance data from 1960-1989, with a focus on the period 1980-1989.

Intervention

Oral poliovirus vaccine (OPV)

Outcome

Incidence of wild-virus, vaccine-associated, and imported paralytic poliomyelitissafety

Vaccine-associated paralytic poliomyelitis has become the predominant form of the disease in the US, suggesting a sequential vaccination schedule (IPV followed by OPV) may reduce risk.

Cite This Study

synapsesocial.com/papers/6a158f60a2f71238514e89f3 https://doi.org/10.1093/clinids/14.2.568

View Full Paper

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Bookmark