February 19, 1997JAMA

Paralytic Poliomyelitis—United States, 1980-1994

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Population

Children in the United States undergoing routine vaccination

Design

Review

Follow-up

1980-1994

Discussion

Reinforces sequential IPV-OPV schedule to address persistent VAPP risk; leaves open whether constancy holds across evolving global programs.

Population

Children in the United States undergoing routine vaccination

Intervention

Sequential vaccination schedule of two doses of inactivated poliovirus vaccine (IPV) followed by two doses of oral poliovirus vaccine (OPV)

Outcome

Incidence of paralytic poliomyelitis and vaccine-associated paralytic poliomyelitis (VAPP)safety

The ACIP recommends a sequential IPV-OPV schedule to mitigate the constant risk of vaccine-associated paralytic poliomyelitis in the US.

A 1997 study studied this question.

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Reinforces sequential IPV-OPV schedule to address persistent VAPP risk; leaves open whether constancy holds across evolving global programs.