Key result
OPV is linked to paralytic polio, with highest risk after the first dose at ~1 per 520,000.
Why the study?
The frequency and characteristics of vaccine-associated paralytic poliomyelitis in the United States from 1973 through 1984 were not fully described.
What is the frequency of vaccine-associated paralytic poliomyelitis following oral polio vaccine administration?
Population
138 cases of paralytic poliomyelitis reported in the United States from 1973 through 1984
Comparison
Vaccine-associated cases in OPV recipients, contacts, immune deficient, and others
Design
Observational case series
Follow-up
1973 through 1984
Authors
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Documents substantial OPV-related paralysis risk; leaves open optimal vaccine strategies for eradication.
Observational (n=138)
What is the frequency of vaccine-associated paralytic poliomyelitis following oral polio vaccine administration?
Vaccine-associated paralytic poliomyelitis is a rare complication of the oral polio vaccine, occurring most frequently with the first dose.
B M Nkowane (1987) conducted an observational in Paralytic poliomyelitis (n=138). Oral polio vaccine (OPV) vs. Subsequent doses was evaluated on Vaccine-associated paralytic poliomyelitis. Oral polio vaccine (OPV) was associated with 105 cases of paralytic poliomyelitis, with the highest risk after the first dose (1 case per 520,000 doses vs 1 per 12.3 million subsequent doses).
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