Population
Plasma from 3-month old male Sprague-Dawley rats, ACE purified from rabbit lung, and rat carotid artery models
Comparison
Nitric oxide donors and an aqueous solution of NO vs Control conditions without NO donors
Design
Preclinical
Authors
Loading...
May physiologically link endothelial NO to RAS regulation; hypothesis-generating in animals but requires human confirmation before any clinical consideration.
This preclinical study demonstrates that nitric oxide competitively inhibits ACE activity, providing a physiological mechanism by which endothelial NO regulates the renin-angiotensin system.
Ackermann et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: