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In this communication, we have examined the effect of 17 O-enriched water on proton T 1ρ relaxation enhancement in aqueous phantoms at high magnetic field strength (2T). 17 O-enriched water produced striking, concentration-dependent alterations in T 1ρ dispersion over a range of spin-lock frequencies between 0.1 and 2.0 kHz. T 1ρ -weighted imaging of the phantoms revealed marked differences in signal intensity that correlated well with H 2 17 O concentration. We propose that the ratio of T 1ρ -weighted images obtained at two different spin-lock frequencies (in the range 0.1-2.0 kHz) can be used to quantify 17 O concentration.
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Reddy et al. (1995) studied this question.
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