Why the study?
Does oral administration of Sabin's attenuated type 1 poliovirus vaccine induce infection and spread differently in children with naturally acquired immunity compared to those with Salk vaccine-induced immunity?
Population
Children in a closed, institutional community
Comparison
Oral administration of Sabin's attenuated type 1… vs Individuals with naturally acquired immunity…
Design
Cohort
Authors
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OPV may transmit asymptomatically among IPV-vaccinated children; leaves open whether natural infection confers superior mucosal resistance in eradication programs.
Does oral administration of Sabin's attenuated type 1 poliovirus vaccine induce infection and spread differently in children with naturally acquired immunity compared to those with Salk vaccine-induced immunity?
The Sabin oral polio vaccine induces symptomless, transmissible infection that easily infects those with Salk vaccine-induced immunity but is resisted by those with naturally acquired immunity.
Dorothy M. Horstmann (1959) studied this question.
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