The outbreak of HFMD in a Beijing Juku was caused by CV-A6, highlighting the need for continuous surveillance of HFMD etiological agents beyond EV-A71 and CV-A16.
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CV-A6 outbreak in Beijing preschool alerts clinicians to emerging strains; leaves open need for prospective surveillance studies.
An outbreak of hand, foot, and mouth disease (HFMD) that occurred in a Juku in Fengtai District, Beijing, China, in 2015 was monitored by the China Information System for Disease Control and Prevention. Epidemiological investigation showed that 11 cases occurred from two classes in the preschool art training department in the Juku. Coxsackievirus A6 (CV-A6) was identified as the causative pathogen of the outbreak via sequences analysis of products of real-time reverse-transcription polymerase chain reaction (RT-PCR) and nested RT-PCR. Phylogenetic analysis showed that CV-A6 strains isolated in this study clustered with epidemic strains isolated in China since 2013. The outbreak ended quickly with effective measures. This event indicates that continuous surveillance of HFMD etiological agents other than enterovirus 71 and coxsackievirus A16 is necessary.
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Li et al. (2016) studied this question.
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