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July 1, 1984Journal of General Virology

The Genomes of Rotaviruses Isolated from Chronically Infected Immunodeficient Children

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Population

2 chronically infected children suffering from severe combined immunodeficiency (rotavirus samples)

Design

Case_series

Authors

SPS. PedleyEnvironment AgencyFHFiona HundleyMRC University of Glasgow Centre for Virus ResearchICI. L. ChrystieGuy's Hospital

Discussion

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Overview

Genome rearrangements may arise in chronic rotavirus infections among immunodeficient children; hypothesis-generating for their impact on viral persistence and transmission.

Structured PICO

P
Population
2 chronically infected children suffering from severe combined immunodeficiency (rotavirus samples)
O
Outcome
RNA migration profiles and sequence homologies of rotavirus dsRNA

Rotaviruses from chronically infected immunodeficient children can develop abnormal RNA migration profiles due to the formation of covalently linked concatemers from lower molecular weight genome segments.

Cite This Study

Pedley et al. (1984) studied this question.

synapsesocial.com/papers/6a9074f3e02ba012352dbea1https://doi.org/10.1099/0022-1317-65-7-1141
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serological analysis of the subgroup protein of rotavirus, using monoclonal antibodies1983 · 358 citations
  2. 2Isolation from Chickens of a Rotavirus Lacking the Rotavirus Group Antigen1981 · 121 citations
  3. 3Rapid Evolution of RNA Genomes1982 · 1,490 citations