Key result
Higher AIP and TyG index linked to ~110% greater risk of incident cardiometabolic multimorbidity.
Why the study?
The associations and predictive performance of the atherogenic index of plasma and triglyceride-glucose index for incident cardiometabolic multimorbidity required comparison.
Do higher atherogenic index of plasma (AIP) and triglyceride-glucose (TyG) index predict incident cardiometabolic multimorbidity in older adults?
Cohort (n=2,261)
Do higher atherogenic index of plasma (AIP) and triglyceride-glucose (TyG) index predict incident cardiometabolic multimorbidity in older adults?
Both AIP and TyG index are similarly associated with incident cardiometabolic multimorbidity and offer modest predictive performance improvements over conventional risk models.
Answers are grounded in this paper and cite their sources.
Composite index may enhance CMM risk stratification in older adults; leaves open whether integration improves outcomes over single indices.
PURPOSE: This study aimed to compare the associations and predictive performance of atherogenic index of plasma (AIP) and the triglyceride-glucose (TyG) index for incident cardiometabolic multimorbidity (CMM). METHODS: Data was analyzed from 2261 adults (mean age 63 years; 45.0% men) in the English Longitudinal Study of Ageing without a history of cardiometabolic disease at baseline (2008-2009). CMM was defined as the occurrence of ≥ 2 of the following conditions by 2021-2023: hypertension, cardiovascular disease, diabetes, or stroke. Multivariable-adjusted odds ratios (ORs) with 95% CIs were estimated. RESULTS: Over 12-15 years of follow-up, 131 cases of CMM were recorded. Higher AIP increased the odds of CMM (per 1-SD increase: OR 1.41, 95% CI 1.15-1.73; highest vs lowest tertile: OR 2.10, 95% CI 1.22-3.60). Similar associations were observed for the TyG index (per 1-SD increase: OR 1.51, 95% CI 1.25-1.82; highest vs lowest tertile: OR 2.07, 95% CI 1.21-3.55). Incorporation of AIP into a conventional risk model resulted in a modest improvement in discrimination, with comparable results observed for the TyG index. CONCLUSION: AIP and the TyG index showed similar positive linear associations with incident CMM and comparable modest predictive performance.
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Kunutsor et al. (2026) conducted a cohort in Cardiometabolic multimorbidity (n=2,261). Atherogenic index of plasma (AIP) and triglyceride-glucose (TyG) index vs. Lowest tertile was evaluated on Incident cardiometabolic multimorbidity (occurrence of ≥ 2 of: hypertension, cardiovascular disease, diabetes, or stroke) (OR 2.10, 95% CI 1.22-3.60). Higher atherogenic index of plasma and triglyceride-glucose index were associated with increased odds of incident cardiometabolic multimorbidity (AIP highest vs lowest tertile OR 2.10; 95% CI 1.22-3.60).
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