Predicting Steady State Serum Concentrations of Drugs

+6745 Mathematical models of biologic processes can be validated both by their abil ity to provide a framework of understanding for already observed phe­ nomena, as well as by prediction of events that have not yet taken place. Clin ical pharmac okinetics is widely accepted as providing useful models for explain ing the behavior of many drugs in the human organism. The predic­ tive value of pharmacok inetic models, however, has been tested less exten­ sively and with somewhat less' success.