Laboratory evaluation demonstrates rapid spectrophotometric estimation of guanethidine sulphate in drug formulations, indicating superior sensitivity over existing pharmacopoeial techniques.
A spectrophotometric method for the estimation of guanethidine sulphate, based on the development of blue colour in alkaline medium after reaction with lithium and sodium molybdophosphotungstate B.P. reagent, is described. The method is more sensitive and rapid than the existing British Pharmacopoeia methods. Both powder and tablets can be estimated by this method.
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Bose et al. (1964) studied this question.
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