Why the study?
Does BMSC-based cell therapy improve the SDF-1 gradient and cardiac function in a rabbit model of chronic myocardial infarction?
Population
Male New Zealand white rabbits with chronic myocardial infarction induced by left anterior descending…
Comparison
2 x 10^6 autologous bone marrow stromal cells… vs Saline injection
Design
Preclinical, randomized
Follow-up
4 weeks
Authors
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Hypothesis-generating for BMSC therapy in chronic MI; requires clinical validation before any practice change.
Does BMSC-based cell therapy improve the SDF-1 gradient and cardiac function in a rabbit model of chronic myocardial infarction?
BMSC-based cell therapy generates a favorable SDF-1 gradient that facilitates stem cell recruitment and improves cardiac function in a rabbit model of chronic myocardial infarction.
Lee et al. (2009) studied this question.
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