July 23, 2014PLoS ONEOpen Access

Genetic Diversity of Human Enterovirus 68 Strains Isolated in Kenya Using the Hypervariable 3′- End of VP1 Gene

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Population

13 EV68 strains isolated from outpatients >2 months old with influenza-like-illness symptoms in Kenya…

Design

Other

Authors

SOSilvanos OpandaKenya Medical Research Institute FWFred WamunyokoliJomo Kenyatta University of Agriculture and Technology SKSamoel KhamadiMuhimbili University of Health and Allied Sciences

Discussion

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Implication

EV68 surveillance in Kenya informs global circulation patterns; leaves open antigenic and clinical implications of clade A dominance.

Structured PICO

Population

13 EV68 strains isolated from outpatients >2 months old with influenza-like-illness (ILI) symptoms in Kenya between 2008 and 2011. Median age 22 months, male:female ratio 10:3.

Intervention

Genetic characterization and phylogenetic analysis based on the Hypervariable 3'-end of the VP1 gene.

Outcome

Genetic diversity, sequence homology, natural selection, and phylogenetic relationships compared to the prototype strain (Fermon) and global strains.

EV68 strains isolated in Kenya are genetically and antigenically divergent from the prototype strain but closely related to globally circulating strains, suggesting worldwide transmissibility.

Limitations

Lack of clinical diagnoses to associate mutations with disease severity
Retrospective study relying on previously obtained isolates may underestimate prevalence
Sole use of VP1 gene obscures possibility of recombination events

Cite This Study

Opanda et al. (2014) studied this question.

synapsesocial.com/papers/6a9079316bfd95d7bd4dea4e https://doi.org/10.1371/journal.pone.0102866

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Genetic Diversity of Human Enterovirus 68 Strains Isolated in Kenya Using the Hypervariable 3′- End of VP1 Gene

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Genetic Diversity of Human Enterovirus 68 Strains Isolated in Kenya Using the Hypervariable 3′- End of VP1 Gene

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider