June 6, 1995Proceedings of the National Academy of SciencesOpen Access

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

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Population

Cell lines including African green monkey kidney Vero cells, transformed human embryonic kidney 293T cells…

Comparison

Treatment with recombinant human IFNa-2a or… vs Untreated cells or mutant cells lacking specific…

Design

Preclinical

Authors

HBHans A.R. BluyssenAdam Mickiewicz University in Poznań RMRana MuzaffarSindh Institute of Urology and Transplantation RVR J Vlieststra

Discussion

Member takes

Implication

Does not support changes to IFN use in cardiovascular patients; leaves open in vivo relevance of p48-STAT91 overlap.

Structured PICO

Population

Cell lines including African green monkey kidney Vero cells, transformed human embryonic kidney 293T cells, human fibrosarcoma 2fTGH cells, and their IFN-unresponsive derivatives (U2A, U3A, U6A).

Intervention

Treatment with recombinant human IFNa-2a or IFNy, and overexpression of ISGF3 components (p48, STAT91, STAT113).

Comparator

Untreated cells or mutant cells lacking specific ISGF3 components.

Outcome

Induction of ISRE-containing genes (e.g., ISG54) and formation of ISGF3 protein complexes.surrogate

The study demonstrates that IFNy can induce ISRE-containing genes through a complex of p48 and STAT91 without requiring STAT113, explaining overlapping transcriptional responses to IFNa and IFNy.

Cite This Study

Bluyssen et al. (1995) studied this question.

synapsesocial.com/papers/6a907936d68f3313dd84227b https://doi.org/10.1073/pnas.92.12.5645

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Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider