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May 31, 2012Journal of VirologyOpen Access

Regulation of Virus Neutralization and the Persistent Fraction by TRIM21

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Population

Cells infected with adenovirus type 5 (a nonenveloped human virus)

Comparison

High TRIM21 expression levels and neutralizing… vs Insufficient amounts of TRIM21 or single-point…

Design

Preclinical

Authors

WMWilliam A. McEwanUniversity of CambridgeFHFelix HaulerElringKlinger (Germany)CWChristopher R. WilliamsUniversity of Colorado Boulder

Discussion

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Overview

Animal models link TRIM21 to antibody neutralization efficacy; leaves open human therapeutic relevance.

Structured PICO

P
Population
Cells infected with adenovirus type 5 (a nonenveloped human virus)
I
Intervention
High TRIM21 expression levels and neutralizing antibody
C
Comparator
Insufficient amounts of TRIM21 or single-point mutations within the TRIM21-binding site in the Fc region of neutralizing antibody
O
Outcome
Virus neutralization and persistent fraction

TRIM21 is an essential intracellular antibody receptor for the effector-driven neutralization of nonenveloped viruses like adenovirus type 5.

Cite This Study

McEwan et al. (2012) studied this question.

synapsesocial.com/papers/6a9079b9fdaee66aea840f66https://doi.org/10.1128/jvi.00728-12
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional basis of poliovirus neutralization determined with monospecific neutralizing antibodies1983 · 104 citations
  2. 2Bivalent attachment of antibody onto poliovirus leads to conformational alteration and neutralization1983 · 84 citations
  3. 3Occupancy and mechanism in antibody-mediated neutralization of animal viruses2002 · 279 citations
  4. 4Mechanisms of Neutralization of Animal Viruses1984 · 138 citations