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March 28, 2005The Journal of Experimental Medicine

Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection

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Authors

CSConnie L. SommersNational Cancer InstituteJLJan LeeNational Institutes of HealthKSKevin SteinerETH Zurich

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Sommers et al. (2005) studied this question.

synapsesocial.com/papers/6a907a06c7b7d4543f89f18bhttps://doi.org/10.1084/jem.20041869
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation2002 · 286 citations
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  3. 3Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells2001 · 142 citations
  4. 4Involvement of p21ras activation in T cell CD69 expression1994 · 153 citations
  5. 5Degree of ERK activation influences both positive and negative thymocyte selection2000 · 58 citations