Why the study?
Can EEG power and coherence discriminate late-onset depression patients with mild cognitive impairment from cognitively unimpaired depressed patients?
Can EEG power and coherence discriminate late-onset depression patients with mild cognitive impairment from cognitively unimpaired depressed patients?
EEG power and coherence at frontotemporal leads may serve as sensitive markers to detect early brain changes suggestive of dementia in patients with late-onset depression and mild cognitive impairment.
EEG changes may discriminate MCI in late-onset depression; leaves open prospective validation before any clinical adoption.
Mild cognitive impairment (MCI) is present in up to 60% of patients with late-onset depression and constitutes a major diagnostic problem in geriatric psychiatry. Searching for sensitive markers for the detection of early brain changes suggestive of dementia, we compared this depressive risk population with mildly to moderately demented patients and cognitively unimpaired depressed patients using EEG power and coherence. We found a considerable similarity between Alzheimer's disease patients and cognitively impaired depressed patients regarding the cognitive profile and EEG pattern. Changes in EEG power and coherence at frontotemporal leads in depressive patients with MCI thereby allowed discrimination from cognitively unimpaired patients with a sensitivity of 88% and a specifity of 81%.
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Brassen et al. (2004) studied this question.
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