Why the study?
Does ezetimibe reduce plasma cholesterol and inhibit atherogenesis in apolipoprotein E knockout (apoE-/-) mice?
Population
Apolipoprotein E knockout mice fed a high-fat 'western' diet, a low-fat diet, or a semisynthetic…
Comparison
Ezetimibe 5 mg/kg per day for 6 months vs No ezetimibe
Design
Preclinical
Follow-up
6 months
Authors
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Supports ezetimibe in preclinical atherosclerosis models; leaves open translation to human therapy.
Does ezetimibe reduce plasma cholesterol and inhibit atherogenesis in apolipoprotein E knockout (apoE-/-) mice?
Ezetimibe significantly reduces plasma cholesterol and inhibits the progression of atherosclerosis in apoE knockout mice across various dietary conditions.
Davis et al. (2001) studied this question.
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