October 7, 2011Journal of Cardiovascular Pharmacology
Efficacy of Colesevelam on Lowering Glycemia and Lipids
Why the study?
Does colesevelam improve glycemic and lipid outcomes?
Population
Patients from 8 trials investigating the efficacy of colesevelam on glycemic and lipid outcomes
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
Supports colesevelam in T2D with hyperlipidemia but cautions against hypertriglyceridemia; extends meta-analytic evidence on dual glycemic-lipid effects.
Structured PICO
Does colesevelam improve glycemic and lipid outcomes?
P
Population
Patients from 8 trials investigating the efficacy of colesevelam on glycemic and lipid outcomes
I
Intervention
Colesevelam
O
Outcome
Plasma fasting glucose, hemoglobin A1c, low-density lipoprotein, high-density lipoprotein, total cholesterol, and triglyceridessurrogate
Colesevelam significantly reduces fasting glucose, HbA1c, and LDL-C, but increases triglycerides, suggesting utility in type 2 diabetics with hyperlipidemia but requiring caution in those with hypertriglyceridemia.
Cite This Study
Aggarwal et al. (2011) studied this question.