Why the study?
Does serum glutamic-oxaloacetic transaminase serve as a reliable measure of myocardial necrosis in humans?
Does serum glutamic-oxaloacetic transaminase serve as a reliable measure of myocardial necrosis in humans?
Serum glutamic-oxaloacetic transaminase is a reliable biomarker for detecting myocardial necrosis, distinguishing it from ischemia without necrosis.
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SGOT elevation may distinguish necrosis from angina; leaves open diagnostic reliability without prospective validation.
Myocardial necrosis in humans was accompanied in over 90% of the cases studied by elevation of the serum glutamic-oxaloacetic transaminase. Serum adenosine triphosphatase and serum lipoprotein lipase were not elevated. Within 36 hours after myocardial infarction the transaminase levels rose to 2-10 times normal and usually returned to normal within 5 days. The myocardial ischemia of angina pectoris was not accompanied by any elevation of transaminase levels.
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Steinberg et al. (1955) studied this question.
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