May 7, 2009Human Molecular GeneticsOpen Access

Positional identification of variants of Adamts16 linked to inherited hypertension

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Population

Rats and human cohorts for genetic association with blood pressure

Design

Preclinical

Authors

BJBina JoeUniversity of Toledo YSYasser SaadBudapest University of Technology and Economics NLNorman H. LeeGeorge Washington University

Discussion

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Implication

ADAMTS16 variants may influence systolic BP; leaves open therapeutic relevance pending functional and clinical validation.

Structured PICO

Population

Rats (inbred, outbred, wild, congenic, S rats) and human cohorts (Quebec Family Study, GenNet) for genetic association with blood pressure

Intervention

Genetic variants of Adamts16 (e.g., rs2086310)

Outcome

Systolic and diastolic blood pressuresurrogate

Adamts16 is identified as a candidate gene controlling blood pressure through high-resolution positional cloning in rats and translational genetic association in humans.

Cite This Study

Joe et al. (2009) studied this question.

synapsesocial.com/papers/6a907b2e7bf96463400d2b03 https://doi.org/10.1093/hmg/ddp218

Topics

Hypertension management

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Positional identification of variants of Adamts16 linked to inherited hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Positional identification of variants of Adamts16 linked to inherited hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider