The study demonstrates that the pathogenicity of the OT strain of mouse encephalomyelitis virus in hamsters can be modulated by alternating host passages.
Host alternation may modulate viral neurovirulence in rodents; leaves open relevance to human disease models pending further validation.
The OT strain of mouse encephalomyelitis virus induces an inapparent infection in suckling hamsters associated with lesions of the central nervous system and skeletal muscles. The virus increases in pathogenicity after alternating mouse-hamster transfers and then induces both paralysis and encephalitis. Pathogenicity is lost through serial hamster passages but is restored by a single mouse transfer.
No takes yet. Share an insight, caveat, or question.
Dean et al. (1948) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: