The adaptation of the MEFl poliomyelitis strain to suckling hamsters yielded a substrain with reduced virulence in primates that can induce neutralizing antibodies, relevant for vaccine development.
Provides attenuated poliovirus candidate for vaccine research; leaves open safety and efficacy in human trials.
The MEFl strain of poliomyelitis virus (Lansing type, Type 2) has been adapted to suckling hamsters using the intracerebral route of inoculation, whereby two substrains of virus have been developed which show a much shortened incubation period and a markedly increased concentration of virus in the nervous tissues. The strains adapted to suckling hamsters have been found to cause paralysis after intramuscular or intraperitoneal inoculation into 21- to 28-day-old mice. 2. Intracerebral inoculations in 20 Rhesus monkeys suggest the MEFl-B substrain of virus has become somewhat reduced in virulence for primates. Two chimpanzees which were fed nervous tissue suspensions of the B substrain remained symptom-free, developed neutralizing antibodies and failed to excrete virus in their stools.
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Moyer et al. (1952) studied this question.
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