June 1, 1949The Journal of Experimental MedicineOpen Access

A Virus Recovered From the Feces of "Poliomyelitis" Patients Pathogenic for Suckling Mice

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Population

Suckling mice, hamsters, and rhesus monkeys inoculated with a virus recovered from the feces of 2 children…

Design

Preclinical

Authors

GDGilbert DalldorfAtkins (United States)GSG. M. SicklesNew York State Department of Health HPH. PlagerNew York State Department of Health

Discussion

Member takes

Implication

Does not support changes in clinical management of poliomyelitis-like illness; leaves open a novel myotropic virus etiology requiring human studies.

Structured PICO

Population

Suckling mice, hamsters, and rhesus monkeys inoculated with a virus recovered from the feces of 2 children with poliomyelitis-like symptoms

Intervention

Inoculation with the recovered virus

Outcome

Pathogenicity and induction of lesions in skeletal muscles versus central nervous systemsurrogate

Identifies a novel virus from patients with poliomyelitis-like symptoms that causes skeletal muscle lesions in suckling mice and hamsters, distinct from typical poliovirus.

Cite This Study

Dalldorf et al. (1949) studied this question.

synapsesocial.com/papers/6a907aeb73c1f5e62dc936b2 https://doi.org/10.1084/jem.89.6.567

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Implication

Does not support changes in clinical management of poliomyelitis-like illness; leaves open a novel myotropic virus etiology requiring human studies.

A Virus Recovered From the Feces of "Poliomyelitis" Patients Pathogenic for Suckling Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Virus Recovered From the Feces of "Poliomyelitis" Patients Pathogenic for Suckling Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider