The study demonstrates that viruses isolated from non-paralytic poliomyelitis and pleurodynia cause distinct pathologic lesions in multiple organs of suckling mice, and myositis is not exclusive to or constant in Coxsackie virus infections.
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Animal models show strain-specific multi-organ lesions beyond myositis; leaves open human disease relevance and requires clinical validation.
A STUDY HAS BEEN MADE OF THE LESIONS PRODUCED IN SUCKLING MICE BY THE FOLLOWING VIRUSES: Powers, Matulaitis, DeMole, Kine, McCarthy, Conn. 5, Ohio R, High Point, WS No. 4, EMC, and Col. SK. Pathologic alterations have been found in myocardium, lungs, liver, pancreas, thymus, brain and spinal cord, adipose tissue, and skeletal muscles. A comparison of the lesions produced by the individual strains has disclosed certain differential features which are discussed in detail. Within the group of so called Coxsackie viruses, myositis has not proved to be a constant finding, and it may occur in suckling mice infected with other types of virus.
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Pappenheimer et al. (1950) studied this question.
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