Coxsackie virus A infection in suckling mice causes progressive structural damage to skeletal muscles followed by regeneration in survivors.
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Supports murine model of Coxsackie myopathy with regeneration; leaves open translation to human disease.
Synopsis An account is given of the changes produced by a particular strain of Coxsackie virus in the skeletal muscles of young mice. These changes are: loss of striations (the “Z” and “H” bands disappearing before the “A” and “I”), swelling of the myofibrillæ, localized œdema, loss of all internal structure with generalized œdema, and finally regeneration if the animal lives.
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F. J. Aumonier (1952) studied this question.
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