Population
4 to 5 day old mice
Design
Preclinical
Follow-up
12 days
Authors
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Suggests viral kinetics drive necrosis timing in this model; leaves open translation to human viral myositis.
This preclinical study demonstrates that Coxsackie virus infection in mice causes acute muscle necrosis that correlates temporally with peak viral concentrations, followed by inflammation and eventual muscle regeneration.
Melnick et al. (1951) studied this question.
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