August 1, 1950The Journal of Experimental MedicineOpen Access

A Viral Agent Isolated From a Case of "Non-Paralytic Poliomyelitis" and Pathogenic for Suckling Mice: Its Possible Relation to the Coxsackie Group of Viruses

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Population

Suckling mice 1 to 2 days old; stool samples from patients with clinical diagnosis of 'non-paralytic…

Comparison

Inoculation with isolated viral agents vs null

Design

Preclinical

Authors

FCF. S. CheeverMassachusetts Eye and Ear Infirmary JDJoan B. DanielsTufts University EHE. Freeman HerseyMassachusetts Department of Public Health

Discussion

Member takes

Implication

No immediate clinical implications; hypothesis-generating for novel viral myocarditis in animal models only.

Structured PICO

Population

Suckling mice 1 to 2 days old; stool samples from patients with clinical diagnosis of 'non-paralytic poliomyelitis'

Intervention

Inoculation with isolated viral agents (Powers, Matulaitis)

Comparator

null

Outcome

Pathogenic lesions in infant mice (myocarditis, adipositis, pancreatitis, hepatitis, encephalomyelitis)surrogate

Isolation of a novel viral agent from a patient with non-paralytic poliomyelitis that causes myocarditis and other systemic lesions in a suckling mouse model.

Cite This Study

Cheever et al. (1950) studied this question.

synapsesocial.com/papers/6a82787f004fcf503374b149 https://doi.org/10.1084/jem.92.2.153

Topics

Myocarditis

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A Viral Agent Isolated From a Case of "Non-Paralytic Poliomyelitis" and Pathogenic for Suckling Mice: Its Possible Relation to the Coxsackie Group of Viruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

A Viral Agent Isolated From a Case of "Non-Paralytic Poliomyelitis" and Pathogenic for Suckling Mice: Its Possible Relation to the Coxsackie Group of Viruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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