March 1, 1980Journal of Neuropathology & Experimental Neurology

Pathogenesis of Human Poliovirus Infection in Mice

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Population

Mice (adults and newborns)

Comparison

Intracerebral inoculation with Lansing type 2… vs Newborn mice; non-immunosuppressed mice

Design

Preclinical

Authors

BJBurk JubeltNorthwestern University GGGhislaine Gallez‐HawkinsCity Of Hope National Medical Center ONOpendra NarayanBendigo Health

Discussion

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Implication

Challenges age-related susceptibility assumptions in viral models; leaves open non-immune mechanisms for targeted investigation.

Structured PICO

Population

Mice (adults and newborns)

Intervention

Intracerebral (ic) inoculation with Lansing type 2 poliovirus; cyclophosphamide immunosuppression

Comparator

Newborn mice (for age comparison); non-immunosuppressed mice

Outcome

Development of disease resembling human poliomyelitis (incidence of paralysis and incubation period)

Intracerebral inoculation of Lansing type 2 poliovirus in mice produces a disease resembling human poliomyelitis, with adult mice showing higher susceptibility than newborns, which is not explained by immune maturation.

Cite This Study

Jubelt et al. (1980) studied this question.

synapsesocial.com/papers/6a8a96fea90c2f4c44fbc63a https://doi.org/10.1097/00005072-198003000-00003

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Pathogenesis of Human Poliovirus Infection in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathogenesis of Human Poliovirus Infection in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider