Population
Mice (n=56)
Comparison
Intracerebral inoculation with Lansing strain… vs Mock-infected mice
Design
Preclinical
Follow-up
up to 77 days
Authors
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Highlights potential CNS viral reservoirs without humoral response; leaves open human relevance and post-polio mechanisms.
The study identifies a prolonged asymptomatic infection in mice intracerebrally inoculated with poliovirus, with viral replication persisting up to 77 days without significant neutralizing antibody response.
James R. Miller (1981) studied this question.
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