Why the study?
Does cyclophosphamide treatment increase persistent CNS infection following attenuated human poliovirus infection in mice?
Population
Cyclophosphamide (CY)-treated mice
Comparison
Attenuated human poliovirus infection vs Untreated mice
Design
Preclinical
Authors
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May increase persistent CNS infection risk under immunosuppression in this model; leaves open relevance to human poliovirus exposure or vaccines.
Does cyclophosphamide treatment increase persistent CNS infection following attenuated human poliovirus infection in mice?
Cyclophosphamide treatment in mice infected with attenuated human poliovirus significantly increases the rate of persistent CNS infection.
Jubelt et al. (1984) studied this question.
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