Population
Adult and newborn mice
Comparison
Intracerebral and intraspinal inoculation of… vs Comparison between adult and newborn mice
Design
Preclinical
Authors
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No clinical implications from this mouse model; leaves open axonal transport mechanisms in human neurotropic infections.
Poliovirus appears to spread within the CNS via an axonal transport system, and maturational changes in fast transport may explain the relative resistance of immature mice to paralysis.
Jubelt et al. (1980) studied this question.
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