January 1, 2007Proceedings of the Japan Academy Series BOpen Access

Molecular aspects of poliovirus pathogenesis

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Population

Transgenic mouse model carrying the human poliovirus receptor, non-transgenic mice, and cultured neural cells

Design

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Authors

ANAkio NomotoTokyo Medical and Dental University

Discussion

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Implication

Transgenic mouse data on poliovirus CNS entry should not change practice; leaves open human relevance of hPVR-independent permeation.

Structured PICO

Population

Transgenic mouse model carrying the human poliovirus receptor (hPVR/CD155), non-transgenic mice, and cultured neural cells

Intervention

Poliovirus inoculation (intravenous, intramuscular, intracerebral, or intraspinal)

Outcome

Molecular mechanisms of viral dissemination (blood-brain barrier permeation and retrograde axonal transport) and neurovirulence

Transgenic mouse models reveal that poliovirus neurovirulence depends primarily on its replication capacity in the CNS rather than dissemination efficiency.

Cite This Study

Akio Nomoto (2007) studied this question.

synapsesocial.com/papers/6a71f2892163a0a01bc5dcd8 https://doi.org/10.2183/pjab.83.266

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Molecular aspects of poliovirus pathogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular aspects of poliovirus pathogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider