Population
Transgenic mice expressing poliovirus receptors (TgPVR mice) and normal mice
Comparison
Intramuscular and intracerebral inoculation of… vs Normal mice inoculated intramuscularly with the…
Design
Preclinical
Authors
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Supports neural spread in TgPVR mice; leaves open relevance to human polio pathogenesis and interventions.
Demonstrates that poliovirus spreads from muscle to the CNS via neural pathways in a transgenic mouse model expressing the human poliovirus receptor.
Ren et al. (1992) studied this question.
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