What does this research mean for the field?

A short sequence of six amino acids in neutralization antigenic site I of the poliovirus capsid is a critical determinant of the virus's host range and its ability to induce neurovirulence in mice. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 8, 1988ScienceOpen Access

Poliovirus Host Range Is Determined by a Short Amino Acid Sequence in Neutralization Antigenic Site I

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Population

Mice (intracerebral inoculation model)

Comparison

Antigenic hybrid poliovirus vs Poliovirus type 1 (Mahoney) and type 2 (Lansing)

Design

Preclinical

Authors

MMMichael G. MurraySouthern Research Institute JBJonathan BradleyCentre National de la Recherche Scientifique XYXiaofeng YangChina Aerodynamics Research and Development Center

Discussion

Member takes

Implication

Hypothesis-generating in mouse models; extends strain adaptation data but leaves open human translation.

Structured PICO

Population

Mice (intracerebral inoculation model)

Intervention

Antigenic hybrid poliovirus (Mahoney strain with 6 amino acids in antigenic site I replaced by Lansing strain sequence)

Comparator

Poliovirus type 1 (Mahoney) and type 2 (Lansing)

Outcome

Induction of paralytic disease/fatal poliomyelitis in micesurrogate

A short amino acid sequence in neutralization antigenic site I is an important determinant of poliovirus host range and mouse neurovirulence.

Cite This Study

Murray et al. (1988) studied this question.

synapsesocial.com/papers/6a1d75331c2cbcb15c5e57e3 https://doi.org/10.1126/science.2838906

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Poliovirus Host Range Is Determined by a Short Amino Acid Sequence in Neutralization Antigenic Site I

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Poliovirus Host Range Is Determined by a Short Amino Acid Sequence in Neutralization Antigenic Site I

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider