Coxsackie B5 infection can present with marked cardiac involvement and orchitis leading to testicular atrophy in young males.
May warrant cardiac evaluation during Coxsackie B5 outbreaks in young males; leaves open true incidence and long-term sequelae.
An outbreak of Coxsackie B5 infection in a group of six male students is reported. Four of the patients had the symptoms of an uncomplicated enterovirus infection with fever, chills, muscular pains etc. In two cases there was, however, marked cardiac involvement with severe chest pains and ECG changes. In addition these two patients had orchitis with secondary testicular atrophy. Immunoglobulin separation and demonstration of IgMantibodies against Coxsackie B5 was used for the confirmation of the virological diagnosis in three of the cases. The value of this technique is discussed in the paper.
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Freij et al. (1970) studied this question.
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