Type I and II Albany strains of Coxsackie virus exhibit specific complement fixation using limb-tissue antigens but lack hemagglutination activity.
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Limb-specific antigens may enable serological typing of Coxsackie strains in models; leaves open translation to human myocarditis diagnostics.
Two Albany strains of Coxsackie virus, Type I (T.T.) and Type II (Fleetwood) were found to be negative for hemagglutination when human O, sheep, chick, and guinea pig erythrocytes were used. On the other hand, the viruses showed distinct positive specific complement fixation without any cross reaction between them. Antigens prepared from infected brain tissue were inactive; those from infected limb tissue were highly active. Tests with human sera and limb-tissue antigens are left for further study.
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Casals et al. (1949) studied this question.
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