Key result
Hemagglutination-inhibition detects homologous response in ~96% of children infected with Coxsackie B virus.
Why the study?
Agglutination of human erythrocytes by Coxsackie B virus types and the use of hemagglutination-inhibition to detect antibody responses in infected children were investigated.
Population
25 children infected with Coxsackie B virus types 3, 4, and 5
Comparison
Hemagglutination-inhibition procedure using Coxsackie B virus types 1, 3, and 5
Design
Observational study testing paired sera
Authors
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Supports HI test for pediatric Coxsackie B serology; leaves open prospective validation before clinical adoption.
Observational (n=25)
Hemagglutination-inhibition is an effective procedure for detecting homologous antibody responses in children infected with Coxsackie B viruses.
Rosen et al. (1961) conducted an observational in Coxsackie B virus infection (n=25). Hemagglutination-inhibition (HI) procedure was evaluated on Significant homologous response. A hemagglutination-inhibition procedure detected a significant homologous response in 24 of 25 children infected with Coxsackie B virus types 3, 4, and 5.
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