DEANE, Shaw and Greep (1) demonstrated hypertrophy and alterations in lipid content of the zona glomerulosa of the adrenal cortex in rats fed a sodium-deficient diet. Their observations have been confirmed by other workers (2, 3) and similar changes have been found in human adrenal glands (4). The purpose of the present investigation was to study further the effects of chronic sodium deficiency in order to correlate the histologic appearance with adrenal steroid secretion in the same animals. The experiments were designed so that the early development and progress of the adrenal alterations could be followed. Chemical data, including steroid secretion, are presented in the preceding paper (5). In this paper, histologic results are presented and their significance discussed with respect to adrenal steroid secretion.
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Hartroft et al. (1957) studied this question.