Infectious Mononucleosis; A Study of 96 Cases

Article1 April 1945INFECTIOUS MONONUCLEOSIS; A STUDY OF 96 CASESJOSEPH H. PRESS, M.D., EDMUND L. SHLEVIN, M.D., ALBERT P. ROSEN, M.D.JOSEPH H. PRESS, M.D., EDMUND L. SHLEVIN, M.D., ALBERT P. ROSEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-4-546 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe study presented in this paper was undertaken for the purpose of evaluating the clinical and laboratory findings in infectious mononucleosis, and of attempting to clarify the criteria supporting the diagnosis of this condition. This statistical analysis is based upon a series of 96 consecutive sporadic cases of infectious mononucleosis observed at the Jewish Hospital of Brooklyn over a 10 year period. This is one of the largest series of sporadic cases of this disease to be reported. Free reference will be made to the literature for purposes of comparison and evaluation of our findings.Definition. Infectious mononucleosis is usually...Bibliography1. DOWNEYMCKINLAY HCA: Acute lymphadenosis compared with acute lymphatic leukemia, Arch. Int. Med., 1923, xxxii, 82. CrossrefGoogle Scholar2. PFEIFFER E: Drüsenfieber, Jahr. f. Kindern., 1889, xxix, 257. Google Scholar3. FILATOW N: Lectures on acute infectious diseases of children, Ed. iv, 1885, A. Lang, Moscow. Google Scholar4. WEST JP: An epidemic of glandular fever, Arch. Pediat., 1896, xiii, 889. Google Scholar5. TÜRK W: Septische Erkrankungen bei Verkümmerung des Granulozytensystems, Wien. klin. Wchnschr., 1907, xx, 157. Google Scholar6. HALL AJ: A case resembling acute lymphatic leukemia, ending in complete recovery, Proc. Roy. Soc. Med., 1915, viii, 15. CrossrefGoogle Scholar7. IRELANDBAETJERRUHRÄH RAWAJ: A case of lymphatic leukemia with apparent cure, Jr. Am. Med. Assoc., 1915, lxv, 948. CrossrefGoogle Scholar8. DEUSSING R: Ueber diphtherieähnliche Anginen mit lymphatischer Reaktion, Deutsch. med. Wchnschr., 1918, xliv, 513 and 542. CrossrefGoogle Scholar9. SPRUNTEVANS TPFA: Mononuclear leukocytosis in reaction to acute infections ("infectious mononucleosis"), Bull. Johns Hopkins Hosp., 1920, xxxi, 410. Google Scholar10. TIDYMORLEY HLEB: Glandular fever, Brit. Med. Jr., 1921, i, 452. CrossrefGoogle Scholar11. PAULBUNNELL JRWW: The presence of heterophile antibodies in infectious mononucleosis, Am. Jr. Med. Sci., 1932, clxxxiii, 90. CrossrefGoogle Scholar12. EPSTEIN SH: Lymphocytic meningitis, Jr. Am. Med. Assoc., 1935, cv, 1792. CrossrefGoogle Scholar13. TIDY HL: Discussion on glandular fever, Proc. Roy. Soc. Med., (Sect. Med.), 1931, xxv, 1. Google Scholar14. HARTFALL SJ: Monocytosis and agranulopenia in Vincent's infection of the mouth and throat, Lancet, 1934, i, 620. CrossrefGoogle Scholar15. BERNSTEIN A: Infectious mononucleosis, Medicine, 1940, xix, 85. CrossrefGoogle Scholar16. DAVIS CM: Acute glandular fever of Pfeiffer, Jr. Am. Med. Assoc., 1929, xcii, 1417. CrossrefGoogle Scholar17. PRICE JP: Infectious mononucleosis, Am. Jr. Dis. Child., 1930, xl, 581. Google Scholar18. MOIR JI: Glandular fever in Falkland Islands, Brit. Med. Jr., 1930, ii, 822. Google Scholar19. PAUL JR: Infectious mononucleosis, Bull. New York Acad. Med., 1939, xv, 43. Google Scholar20. GLANZMANN E: Das lymphaemoide Drüsenfieber, Berlin, S. Karger, 235, pp. 1930. Google Scholar21. NYFELDT A: Klinische und experimentelle Untersuchungen über die Mononucleosis infectiosa, Folia haemat., 1932, xlvii, 1. Google Scholar22. LONGCOPE WT: Infectious mononucleosis (glandular fever) with a report of ten cases, Am. Jr. Med. Sci., 1922, clxiv, 781. CrossrefGoogle Scholar23. GOODING SE: On glandular fever or infective mononucleosis, Practitioner, 1931, cxxvii, 468. Google Scholar24. NOLAN RA: Report of so-called epidemic of glandular fever (infectious mononucleosis), United States Nav. Med. Bull., 1935, xxxiii, 479. Google Scholar25. DOWNEYSTASNEY HJ: The pathology of the lymph nodes in infectious mononucleosis, Folia haemat., 1936, liv, 417. Google Scholar26. PRATT CL: The pathology of glandular fever, Lancet, 1931, ii, 794. CrossrefGoogle Scholar27. HANGANUTZIU M: Hémagglutinines hétérogénétiques après injection de sérum de cheval, Compt.-rend. Soc. de biol., 1924, ii, 1457. Google Scholar28. BALDRIDGEROHNERHANSMANN CWFJGH: Glandular fever (infectious mononucleosis), Arch. Int. Med., 1926, xxxviii, 413. CrossrefGoogle Scholar29. TIDY HL: Glandular fever and infectious mononucleosis, Lancet, 1934, ii, 180 and 236. CrossrefGoogle Scholar30. CHEVALLIER P: L'adénolymphoïdte aiguë bénigne avec hyperleucocytose modérée et forte mononucléose, Sang, 1928, ii, 166. Google Scholar31. BURNS JE: Glandular fever. Report of an epidemic in the children's ward of the Union Protestant Infirmary, Arch. Int. Med., 1909, iv, 118. CrossrefGoogle Scholar32. OLESON M: Infectious mononucleosis in sisters, examined by vital staining and for heterophile antibodies: two cases, Abst., Jr. Am. Med. Assoc., 1934, cii, 1350. Google Scholar33. MCKINLAY CA: Infectious mononucleosis, Jr. Am. Med. Assoc., 1935, cv, 761. CrossrefGoogle Scholar34. SCHEER K: Eine Epidemie des Pfeifferschen Drüsenfiebers, Monatsschr. f. Kindern., 1930, xlviii, 59. Google Scholar35. BENSON WT: Glandular fever or infective mononucleosis, Edinburgh Med. Jr., 1932, xxxix, 63. Google Scholar36. GUTHRIEPESSEL CCJF: An epidemic of "glandular fever" in a preparatory school for boys, Am. Jr. Dis. Child., 1925, xxix, 492. Google Scholar37. BASSHERMAN MHH: Infectious mononucleosis in childhood, Med. Clin. N. Am., 1925, ix, 589. Google Scholar38. DE VRIES SI: The icteric form of glandular fever, Acta med. Scandinav., 1938, xcv, 552. Google Scholar39. MORRISONSAMWICK MAA: Clinico-hematologic evaluation of bone marrow biopsies, Am. Jr. Med. Sci., 1939, cxcviii, 758. CrossrefGoogle Scholar40. MORRISON M: Personal communication. Google Scholar41. DAVIDSOHN I: Serologic diagnosis of infectious mononucleosis, Jr. Am. Med. Assoc., 1937, cviii, 289. CrossrefGoogle Scholar42. DE BRUIN M: Over lymphatische reactie, klierkoorts en lymphotrope vira, Nederl. tijdschr. v. geneesk., 1930, lxxiv, 5828. Google Scholar43. FARLEY DL: Acute infectious mononucleosis, Med. Clin. N. Am., 1937, xxi, 1139. CrossrefGoogle Scholar44. STUARTBURGESSLAWSONWELLMAN CAAMHAHE: Some cytologic and serologic aspects of infectious mononucleosis, Arch. Int. Med., 1934, liv, 199. CrossrefGoogle Scholar45. ISRAËLS MC: Infectious mononucleosis (glandular fever) and monocytic leukemia, Brit. Med. Jr., 1937, i, 601. CrossrefGoogle Scholar46. GALL EA: The diagnostic value of supravital staining in infectious mononucleosis, Am. Jr. Med. Sci., 1937, cxciv, 546. CrossrefGoogle Scholar47. OSGOOD EE: Fenestration of nuclei of lymphocytes: a new diagnostic sign in infectious mononucleosis, Proc. Soc. Exper. Biol. and Med., 1935, xxxiii, 218. CrossrefGoogle Scholar48. COTTRELL JE: Infectious mononucleosis, Am. Jr. Med. Sci., 1927, clxxiii, 472. CrossrefGoogle Scholar49. MONTGOMERY LC: A case of infectious mononucleosis, Canad. Med. Assoc. Jr., 1930, xxii, 235. Google Scholar50. BAILEYRAFFEL GHS: Hemolytic antibodies for sheep and ox erythrocytes in infectious mononucleosis, Jr. Clin. Invest., 1935, xiv, 228. CrossrefGoogle Scholar51. BEER P: Heterophile antibodies in infectious mononucleosis and after injection of serum, Jr. Clin. Invest., 1936, xv, 591. CrossrefGoogle Scholar52. DAVIDSOHNWALKER IP: The nature of the heterophile antibodies in infectious mononucleosis, Am. Jr. Clin. Path., 1935, v, 455. CrossrefGoogle Scholar53. DAVIDSOHN I: Test for infectious mononucleosis, Am. Jr. Clin. Path., 1938, viii, 56. CrossrefGoogle Scholar54. BERNSTEIN A: Antibody responses in infectious mononucleosis, Jr. Clin. Invest., 1934, xiii, 419. CrossrefGoogle Scholar55. BRUYNOGHE G: Contribution a l'étude des antigènes hétérogéniques, Arch. internat. de méd. expér., 1937, xii, 397. Google Scholar56. STUARTTALLMANBRINTZENHOFF CAJE: Sheep and rabbit cell agglutinins in horse serum sickness and infectious mononucleosis, Jr. Immunol., 1935, xxviii, 85. Google Scholar57. FORSSMAN J: Die Herstellung hochwertiger spezifischer Schafhämolysine ohne Verwendung von Schafblut, Biochem. Ztschr., 1911, xxxvii, 78. Google Scholar58. DAVIDSOHN I: Heterophile antibodies in serum sickness, Jr. Immunol., 1929, xvi, 259. Google Scholar59. ERF LA: Acute infectious mononucleosis with unidentified structures in the supravital preparations of the lymph nodes, Jr. Mt. Sinai Hosp., 1936-1937, iii, 113. Google Scholar60. ROSENTHALWENCKEBACH NG: Die Bedeutung der heterophilen Antikörperreaktion für die Diagnose der infektiösen Mononucleose, Klin. Wchnschr., 1933, xii, 499. CrossrefGoogle Scholar61. DAVIDSOHN I: Discussion of MCKINLAY'S paper.33 Google Scholar62. LÖHEROSENFELD HH: Über Monozytenangina mit anschliessendem vorübergehend seropositiven Erythema nodosum, zugleich ein Beitrag zur Differentialdiagnose zwischen luetischer und nichtluetischer Angina, Dermat. Ztschr., 1928, liii, 373. CrossrefGoogle Scholar63. WEBER FP: Glandular fever and its lymphotropic blood picture, sometimes without obvious glandular enlargement, Med. Press, 1930, clxxxi, 65. Google Scholar64. RADFORDROLLESTON MJD: Two cases of glandular fever simulating typhus, Lancet, 1930, ii, 18. CrossrefGoogle Scholar65. WEBERBODE FPOB: Beiträge zum "Drüsenfieber," München. med. Wchnschr., 1931, lxxviii, 1598. Google Scholar66. PRIEST R: Glandular fever, Jr. Roy. Army Med. Corps, 1935, lxv, 159. Google Scholar67. BERNSTEIN A: False-positive Wassermann reactions in infectious mononucleosis, Am. Jr. Med. Sci., 1938, cxcvi, 79. CrossrefGoogle Scholar68. ASAHINA K: Positive Hanganutziu-Deichersche Reaktion bei endemischem Fieber in Süd-Japan, Nagoya Jr. Med. Sci., 1937, xi, 79. Google Scholar69. KAHN RL: Are there paradoxic serologic reactions in syphilis?, Arch. Dermat. and Syph., 1939, xxxix, 92. CrossrefGoogle Scholar70. MILLS J: Glandular fever, Roy. Berkshire Hosp. Rep., 1932, 66. Google Scholar71. GILBERT-DREYFUS M: Angine à monocytes à forme hémorragique, Bull. et mém. Soc. méd. d. hôp. de Paris, 1933, xlix, 1408. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication May 29, 1944.From the Medical Service of Dr. Edmund L. Shlevin, The Jewish Hospital of Brooklyn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders)Epstein–Barr Virus (Mononucleosis and Lymphoproliferative Disorders)Epstein–Barr Virus Infections (Mononucleosis and Lymphoproliferative Disorders)Epidemiology and clinical manifestations of herpesvirus infections in infants and childrenLimitations of available tests for diagnosis of infectious mononucleosisInfectious Mononucleosis: Age, Civil State and Pregnancy-an Epidemiological StudyThe incidence of glandular feverGranulocyte changes in infectious mononucleosisREFERENCESInfectious Mononucleosis An Epidemiological and Clinical StudyInfectious mononucleosisInfectious mononucleosisInfectious Mononucleosis with Intense Jaundice of Long Duration 1 April 1945Volume 22, Issue 4Page: 546-562KeywordsClinical laboratoriesMedical servicesResearch laboratories Issue Published: 1 April 1945 PDF downloadLoading ...