Key result
Horse serum sickness was associated with the presence of agglutinins for sheep blood in 100% of patients, compared to 4.2% of controls without a history of serum sickness.
Population
21 patients with horse serum sickness and 450 control cases with no history of serum sickness
Design
Case-control
Authors
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May support heterophile antibody screening in serum sickness; leaves open diagnostic utility and relevance to modern exposures.
Observational (n=471)
Absolute Event Rate: 100% vs 4.2%
Patients with horse serum sickness consistently develop heterophile antibodies (agglutinins and hemolysins) against sheep blood.
I. Davidsohn (1929) conducted an observational in Horse serum sickness (n=471). Horse serum sickness vs. No history of serum sickness was evaluated on Presence of agglutinins for sheep blood. Horse serum sickness was associated with the presence of agglutinins for sheep blood in 100% of patients, compared to 4.2% of controls without a history of serum sickness.
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