control subjects. The patient with gout and psoriasis (F.M.) had a history of frequent attacks of acute arthritis which responded to colchicine. A synovial biopsy of his left knee revealed characteristic deposition of urate crystals. The control subjects had no family history or stigmata of either psoriasis or gout. Remission of psoriasis occurred in one patient (L.P.) following a severe drug eruption resulting from the oral administration of chloroquin phosphate. Within 2 weeks after the drug had been discontinued, complete healing of the skin had occurred and no lesions of psoriasis were present. The repeat glycine-1-C1' incorporation study was carried out approximately 10 weeks after the last dose of chloroquin had been administered, while the psoriasis was still in complete remission. All subjects were hospitalized throughout the studies and were maintained on a standard 2,600 calorie diet, essentially free of purines and containing 70 g of protein, 350 g of carbohydrate and 100 g of fat. At least 5 days were allowed for equilibration on the diet before the studies were performed. Patients received no medication during the study. The clinical diagnosis of psoriasis in each case was confirmed by skin biopsy. Renal function was assessed by routine urinalysis, blood urea nitrogen and phenolsulfonphthalein excretion. Daily 24-hour urine collections were preserved with
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Eisen et al. (1961) studied this question.