Why the study?
Does fosinopril prevent the development of early atherosclerosis in LDL-receptor-deficient mice?
Population
45 LDL-receptor-deficient mice fed a high-fat, high-cholesterol western diet
Comparison
Fosinopril 0.01 mg/kg/day or 0.1 mg/kg/day in… vs Distilled water (control group)
Design
Preclinical
Follow-up
10 weeks
Authors
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Fosinopril does not prevent early atherosclerosis in LDLR-deficient mice; leaves open RAAS effects in other models, stages, or humans.
Does fosinopril prevent the development of early atherosclerosis in LDL-receptor-deficient mice?
Inhibition of the renin-angiotensin-aldosterone axis with fosinopril does not prevent early atherosclerosis development in LDL-receptor-deficient mice, despite lowering plasma aldosterone.
Sharabi et al. (2000) studied this question.
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