Why the study?
Does local cooling of specialized cardiac tissues suppress impulse formation and induce reversible atrioventricular block in unanesthetized dogs?
Does local cooling of specialized cardiac tissues suppress impulse formation and induce reversible atrioventricular block in unanesthetized dogs?
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Surgically implanted cooling devices can reversibly block specialized cardiac tissue conduction in unanesthetized dogs, demonstrating a method for physiological heart rate control.
The sinoatrial node and the bundle of His in intact, unanesthetized dogs were subjected to local cooling by means of surgically implanted devices. Impulse formation in the sinoatrial node could thus be suppressed at will and the heart rate regulated within a physiological range by an electrode driving the atrium. Reversible blockage of atrioventricular conduction was easily induced on cooling the region of the bundle of His.
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Lister et al. (1964) studied this question.
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