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October 1, 1961Archives of Surgery

Surgical Heart Block

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Why the study?

What are the hemodynamic effects of electrical stimulation, temperature variations, isoproterenol, and digitalis in a canine model of complete heart block?

Population

20 mongrel dogs with complete heart block induced by ligation of the bundle of His under light thiopental…

Design

Preclinical

Follow-up

Up to 2 days

Authors

VWVallee L. Willman

Discussion

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Overview

Establishes canine model for complete heart block hemodynamics; leaves open translation to clinical pacing and pharmacologic strategies.

Key Points

  • This investigation assesses how electrical stimulation and various drugs affect heart function in complete heart block.
  • Complete heart block was induced in 20 mongrel dogs by ligation of the bundle of His.
  • Mean systemic arterial pressure, cardiac rate, mean left atrial pressure, and cardiac output were measured using a dye-dilution technique.
  • Fifteen animals were studied immediately, while five were studied after recovery 2 days later.
  • Electrical stimulation improved cardiac output in the dogs with complete heart block.
  • Isoproterenol showed a significant increase in cardiac rate compared to baseline measures.
  • Digitalis administration resulted in improved mean systemic arterial pressure and left atrial pressure.

Structured PICO

What are the hemodynamic effects of electrical stimulation, temperature variations, isoproterenol, and digitalis in a canine model of complete heart block?

P
Population
20 mongrel dogs with complete heart block induced by ligation of the bundle of His under light thiopental sodium anesthesia
I
Intervention
Electrical stimulation, variations in temperature, isoproterenol, and digitalis
O
Outcome
Mean systemic arterial pressure, cardiac rate, mean left atrial pressure, and cardiac outputsurrogate

This preclinical study describes a canine model of surgically induced complete heart block to evaluate the hemodynamic effects of pacing and pharmacological interventions.

Cite This Study

Vallee L. Willman (1961) studied this question.

synapsesocial.com/papers/6a20826015df8032213e8ec0https://doi.org/10.1001/archsurg.1961.01300160008002
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